Exploring the neuroprotective effects of montelukast on brain inflammation and metabolism in a rat model of quinolinic acid-induced striatal neurotoxicity

Exploring the neuroprotective effects of montelukast on brain inflammation and metabolism in a rat model of quinolinic acid-induced striatal neurotoxicity

Abstract Background One intrastriatal administration of quinolinic acid (QA) in rats induces a lesion with features resembling those observed in Huntington’s disease. Our aim is to evaluate the effects of the cysteinyl leukotriene receptor antagonist montelukast (MLK), which exhibited neuroprotectio...

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Bibliographic Details
Main Authors: Margherita Tassan Mazzocco, Valentina Murtaj, Daniel Martins, Roberta Schellino, Angela Coliva, Elisa Toninelli, Alessandro Vercelli, Federico Turkheimer, Sara Belloli, Rosa Maria Moresco
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Neuroinflammation
Subjects:
Montelukast
Neuroinflammation
Positron emission tomography
Quinolinic acid
Neurodegeneration
Cysteinyl leukotriene receptor antagonist
Online Access:https://doi.org/10.1186/s12974-023-02714-z

Internet

https://doi.org/10.1186/s12974-023-02714-z

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