Lipocalin-2: a therapeutic target to overcome neurodegenerative diseases by regulating reactive astrogliosis

Abstract Glial cell activation precedes neuronal cell death during brain aging and the progression of neurodegenerative diseases. Under neuroinflammatory stress conditions, lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin or 24p3, is produced and secreted by activated mic...

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Bibliographic Details
Main Authors: Byung-Kwon Jung, Kwon-Yul Ryu
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-01098-7