Immunoinformatics Design and In Vivo Immunogenicity Evaluation of a Conserved CTL Multi-Epitope Vaccine Targeting HPV16 E5, E6, and E7 Proteins

Immunoinformatics Design and In Vivo Immunogenicity Evaluation of a Conserved CTL Multi-Epitope Vaccine Targeting HPV16 E5, E6, and E7 Proteins

Human papillomavirus type 16 (HPV16) infection is responsible for more than 50% of global cervical cancer cases. The development of a vaccine based on cytotoxic T-lymphocyte (CTL) epitopes is a promising strategy for eliminating pre-existing HPV infections and treating patients with cervical cancer....

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Bibliographic Details
Main Authors: Ni Guo, Zhixin Niu, Zhiling Yan, Weipeng Liu, Lei Shi, Chuanyin Li, Yufeng Yao, Li Shi
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Vaccines
Subjects:
human papilloma virus type 16 (HPV16)
immunoinformatics
CTL epitope prediction
multi-epitope vaccine design
tumor immunotherapy
Online Access:https://www.mdpi.com/2076-393X/12/4/392

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https://www.mdpi.com/2076-393X/12/4/392

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