Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway

Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway

Abstract Background The aggressive phenotype of fibroblast-like synoviocytes (FLS) has been identified as a contributing factor to the exacerbation of rheumatoid arthritis (RA) through the promotion of synovitis and cartilage damage. Regrettably, there is currently no effective therapeutic intervent...

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Bibliographic Details
Main Authors: Dong Guo, Haoyan Pan, Xueying Lu, Zhong Chen, Laixi Zhou, Shuxin Chen, Jin Huang, Xinzhi Liang, Zhisheng Xiao, Hua Zeng, Yan Shao, Weizhong Qi, Denghui Xie, Chuangxin Lin
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Arthritis Research & Therapy
Subjects:
Rspo2
Fibroblast-like synoviocyte
Chondrocyte
Synovitis
Wnt/ β-catenin
Rheumatoid arthritis
Online Access:https://doi.org/10.1186/s13075-023-03198-1

Internet

https://doi.org/10.1186/s13075-023-03198-1

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