Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions

Abstract We built a computational model of complex mechanisms at the intersection of immunity and metabolism that regulate CD4+ T cell effector and regulatory functions by using coupled ordinary differential equations. The model provides an improved understanding of how CD4+ T cells are shaping the...

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Bibliographic Details
Main Authors: Ryan Baker, Raquel Hontecillas, Nuria Tubau-Juni, Andrew J. Leber, Shiv Kale, Josep Bassaganya-Riera
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-022-00263-4