Effect of Antibiotic Amphotericin B Combinations with Selected 1,3,4-Thiadiazole Derivatives on RPTECs in an In Vitro Model

Effect of Antibiotic Amphotericin B Combinations with Selected 1,3,4-Thiadiazole Derivatives on RPTECs in an In Vitro Model

4-(5-methyl-1,3,4-thiadiazole-2-yl) benzene-1,3-diol (C1) and 4-[5-(naphthalen-1-ylmethyl)-1,3,4-thiadiazol-2-yl] benzene1,3-diol (NTBD) are representative derivatives of the thiadiazole group, with a high antimycotic potential and minimal toxicity against normal human fibroblast cells. The present...

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Bibliographic Details
Main Authors: Agnieszka Dróżdż, Adrianna Sławińska-Brych, Dominika Kubera, Magdalena Kimsa-Dudek, Joanna Magdalena Gola, Jolanta Adamska, Celina Kruszniewska-Rajs, Arkadiusz Matwijczuk, Dariusz Karcz, Wojciech Dąbrowski, Andrzej Stepulak, Mariusz Gagoś
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
1,3,4-thiadiazole derivatives
amphotericin B
RPTEC model
caspase activity
cell viability
cell apoptosis
Online Access:https://www.mdpi.com/1422-0067/23/23/15260

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https://www.mdpi.com/1422-0067/23/23/15260

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