Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway.

Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway.

BACKGROUND: Phosphoinositide 3-kinase (PI3K)/Akt pathway is linked to the development of asthma. Anti-malarial drug artesunate is a semi-synthetic derivative of artemisinin, the principal active component of a medicinal plant Artemisia annua, and has been shown to inhibit PI3K/Akt activity. We hypot...

Full description

Bibliographic Details
Main Authors: Chang Cheng, W Eugene Ho, Fera Y Goh, Shou Ping Guan, Li Ren Kong, Wen-Qi Lai, Bernard P Leung, W S Fred Wong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3111464?pdf=render

Internet

http://europepmc.org/articles/PMC3111464?pdf=render

Similar Items