Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal

Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal

Background/Aims: Reactive dicarbonyl compounds, such as methylglyoxal (MG), contribute to diabetic complications. MG-scavenging capacities of carnosine and anserine, which have been shown to mitigate diabetic nephropathy, were evaluated in vitro and in vivo. Methods: MG-induced cell toxicity was cha...

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Bibliographic Details
Main Authors: Tim Weigand, Benjamin Singler, Thomas Fleming, Peter Nawroth, Karel D. Klika, Christian Thiel, Hans Baelde, Sven F. Garbade, Andreas H. Wagner, Markus Hecker, Benito A. Yard, Albert Amberger, Johannes Zschocke, Claus P. Schmitt, Verena Peters
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Diabetic nephropathy
Carnosine
Anserine
Methylglyoxal
Renal cells
Taurine transporter
Online Access:https://www.karger.com/Article/FullText/488727

Internet

https://www.karger.com/Article/FullText/488727

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