The Potent Trypanocidal Effect of LQB303, a Novel Redox-Active Phenyl-Tert-Butyl-Nitrone Derivate That Causes Mitochondrial Collapse in Trypanosoma cruzi

The Potent Trypanocidal Effect of LQB303, a Novel Redox-Active Phenyl-Tert-Butyl-Nitrone Derivate That Causes Mitochondrial Collapse in Trypanosoma cruzi

Chagas disease, which is caused by Trypanosoma cruzi, establishes lifelong infections in humans and other mammals that lead to severe cardiac and gastrointestinal complications despite the competent immune response of the hosts. Furthermore, it is a neglected disease that affects 8 million people wo...

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Bibliographic Details
Main Authors: Carolina Machado Macedo, Francis Monique de Souza Saraiva, Jéssica Isis Oliveira Paula, Suelen de Brito Nascimento, Débora de Souza dos Santos Costa, Paulo Roberto Ribeiro Costa, Ayres Guimarães Dias, Marcia Cristina Paes, Natália Pereira Nogueira
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Microbiology
Subjects:
Trypanosoma cruzi
chemotherapy
bioenergetics
high-resolution respirometry
mitochondrion
tropical neglected disease
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.617504/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.617504/full

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