Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity

Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity

Abstract Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and how exosomes modulate Aβ neurotoxicity in Alzheimer’s disease (AD). We show here that brain tissue and serum from the transgenic mouse model of familial AD (5xFAD) and serum from AD patients c...

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Bibliographic Details
Main Authors: Ahmed Elsherbini, Alexander S. Kirov, Michael B. Dinkins, Guanghu Wang, Haiyan Qin, Zhihui Zhu, Priyanka Tripathi, Simone M. Crivelli, Erhard Bieberich
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Acta Neuropathologica Communications
Subjects:
Astrocytes
Exosomes
Mitochondria
Ceramide
Amyloid
Online Access:http://link.springer.com/article/10.1186/s40478-020-00931-8

Internet

http://link.springer.com/article/10.1186/s40478-020-00931-8

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