Structure-Based Virtual Screening and De Novo Design of PIM1 Inhibitors with Anticancer Activity from Natural Products

Structure-Based Virtual Screening and De Novo Design of PIM1 Inhibitors with Anticancer Activity from Natural Products

Background: the proviral insertion site of Moloney murine leukemia (PIM) 1 kinase has served as a therapeutic target for various human cancers due to the enhancement of cell proliferation and the inhibition of apoptosis. Methods: to identify effective PIM1 kinase inhibitors, structure-based virtual...

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Bibliographic Details
Main Authors: Hwangseo Park, Jinwon Jeon, Kewon Kim, Soyeon Choi, Sungwoo Hong
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceuticals
Subjects:
virtual screening
de novo design
PIM1
natural products
anticancer activity
Online Access:https://www.mdpi.com/1424-8247/14/3/275

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https://www.mdpi.com/1424-8247/14/3/275

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