Alzheimer’s disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression

The synapse has consistently been considered a vulnerable and critical target within Alzheimer’s disease, and synapse loss is, to date, one of the main biological correlates of cognitive decline within Alzheimer’s disease. This occurs prior to neuronal loss with ample evidence that synaptic dysfunct...

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Bibliographic Details
Main Authors: Soraya Meftah, Jian Gan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2023.1129036/full