Gut microbiome-derived glycine lipids are diet-dependent modulators of hepatic injury and atherosclerosis

Gut microbiome-derived glycine lipids are diet-dependent modulators of hepatic injury and atherosclerosis

Oral and gut Bacteroidetes produce unique classes of serine-glycine lipodipeptides and glycine aminolipids that signal through host Toll-like receptor 2. These glycine lipids have also been detected in human arteries, but their effects on atherosclerosis are unknown. Here, we sought to investigate t...

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Bibliographic Details
Main Authors: Courtney L. Millar, Liya Anto, Chelsea Garcia, Mi-Bo Kim, Anisha Jain, Anthony A. Provatas, Robert B. Clark, Ji-Young Lee, Frank C. Nichols, Christopher N. Blesso
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Journal of Lipid Research
Subjects:
liver
dietary fat
cholesterol
heart
inflammation
high-fat diet
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000256

Internet

http://www.sciencedirect.com/science/article/pii/S0022227522000256

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