Cross-reactive antibodies targeting surface-exposed non-structural protein 1 (NS1) of dengue virus-infected cells recognize epitopes on the spaghetti loop of the β-ladder domain.

Cross-reactive antibodies targeting surface-exposed non-structural protein 1 (NS1) of dengue virus-infected cells recognize epitopes on the spaghetti loop of the β-ladder domain.

Non-structural protein 1 (NS1) is a glycoprotein component of dengue virus (DENV) that is essential for viral replication, infection and immune evasion. Immunization with NS1 has been shown to elicit antibody-mediated immune responses which protect mice against DENV infections. Here, we obtained per...

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Bibliographic Details
Main Authors: Romchat Kraivong, Somchoke Traewachiwiphak, Napon Nilchan, Nattaya Tangthawornchaikul, Nuntaya Pornmun, Ranyikar Poraha, Kanokwan Sriruksa, Wannee Limpitikul, Panisadee Avirutnan, Prida Malasit, Chunya Puttikhunt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0266136

Internet

https://doi.org/10.1371/journal.pone.0266136

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