Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

Summary: Nucleocapsid (N) protein of the SARS-CoV-2 virus packages the viral genome into well-defined ribonucleoprotein particles, but the molecular pathway is still unclear. N-protein is dimeric and consists of two folded domains with nucleic acid (NA) binding sites, surrounded by intrinsically dis...

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Bibliographic Details
Main Authors: Huaying Zhao, Di Wu, Ai Nguyen, Yan Li, Regina C. Adão, Eugene Valkov, George H. Patterson, Grzegorz Piszczek, Peter Schuck
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Virology
Biophysics
protein folding
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221004910

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221004910

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