Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old

Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old

Summary: Background: Advanced age is accompanied by a decline of immune functions, which may play a role in increased vulnerability to emerging pathogens and low efficacy of primary vaccinations in elderly people. The capacity to mount immune responses against new antigens is particularly affected...

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Bibliographic Details
Main Authors: Francesco Nicoli, Emmanuel Clave, Kerstin Wanke, Amrei von Braun, Vincent Bondet, Cécile Alanio, Corinne Douay, Margaux Baque, Claire Lependu, Peggy Marconi, Karin Stiasny, Franz X. Heinz, Margot Muetsch, Darragh Duffy, Jacques Boddaert, Delphine Sauce, Antoine Toubert, Urs Karrer, Victor Appay
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:EBioMedicine
Subjects:
Naive T lymphocytes
Thymus
Elderly
T-cell responses
Vaccines
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422000366

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http://www.sciencedirect.com/science/article/pii/S2352396422000366

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