Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation
Abstract Understanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of the basal ganglia. Here, we developed a custom three-chambered microfluidic platform and established a cortico-striato-nigral microcircuit pa...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-04-01
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Series: | npj Parkinson's Disease |
Online Access: | https://doi.org/10.1038/s41531-024-00694-2 |