Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation

Abstract Understanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of the basal ganglia. Here, we developed a custom three-chambered microfluidic platform and established a cortico-striato-nigral microcircuit pa...

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Bibliographic Details
Main Authors: Quyen B. Do, Humaira Noor, Ricardo Marquez-Gomez, Kaitlyn M. L. Cramb, Bryan Ng, Ajantha Abbey, Naroa Ibarra-Aizpurua, Maria Claudia Caiazza, Parnaz Sharifi, Charmaine Lang, Dayne Beccano-Kelly, Jimena Baleriola, Nora Bengoa-Vergniory, Richard Wade-Martins
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00694-2

Internet

https://doi.org/10.1038/s41531-024-00694-2

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