Pharmacokinetics, Pharmacodynamics, and Dosing Considerations of Novel β-Lactams and β-Lactam/β-Lactamase Inhibitors in Critically Ill Adult Patients: Focus on Obesity, Augmented Renal Clearance, Renal Replacement Therapies, and Extracorporeal Membrane Oxygenation

Pharmacokinetics, Pharmacodynamics, and Dosing Considerations of Novel β-Lactams and β-Lactam/β-Lactamase Inhibitors in Critically Ill Adult Patients: Focus on Obesity, Augmented Renal Clearance, Renal Replacement Therapies, and Extracorporeal Membrane Oxygenation

Objective: Dose optimization of novel β-lactam antibiotics (NBLA) has become necessary given the increased prevalence of multidrug-resistant infections in intensive care units coupled with the limited number of available treatment options. Unfortunately, recommended dose regimens of NBLA based on PK...

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Bibliographic Details
Main Authors: Dana Bakdach, Reem Elajez, Abdul Rahman Bakdach, Ahmed Awaisu, Gennaro De Pascale, Ali Ait Hssain
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Journal of Clinical Medicine
Subjects:
novel beta-lactam antibiotics
critical care
augmented renal clearance
extracorporeal membrane oxygenation
renal replacement
obesity
Online Access:https://www.mdpi.com/2077-0383/11/23/6898

Internet

https://www.mdpi.com/2077-0383/11/23/6898

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