ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression

ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression

Adenovirus-mediated overexpression of human apolipoprotein E (apoE) induces hyperlipidemia by stimulating the VLDL-triglyceride (TG) production rate and inhibiting the LPL-mediated VLDL-TG hydrolysis rate. Because apoC-III is a strong inhibitor of TG hydrolysis, we questioned whether Apoc3 deficienc...

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Dettagli Bibliografici
Autori principali: Gery Gerritsen, Patrick C.N. Rensen, Kyriakos E. Kypreos, Vassilis I. Zannis, Louis M. Havekes, Ko Willems van Dijk
Natura: Articolo
Lingua:English
Pubblicazione: Elsevier 2005-07-01
Serie:Journal of Lipid Research
Soggetti:
lipoprotein lipase-mediated triglyceride hydrolysis
adenovirus-mediated gene transfer
mice
very low density lipoprotein
apolipoprotein E
apolipoprotein C-III
Accesso online:http://www.sciencedirect.com/science/article/pii/S0022227520329989

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http://www.sciencedirect.com/science/article/pii/S0022227520329989

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