Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance

Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance

Background & Aims: Lipotoxicity triggers non-alcoholic fatty liver disease (NAFLD) progression owing to the accumulation of toxic lipids in hepatocytes including saturated fatty acids (SFAs), which activate pro-inflammatory pathways. We investigated the impact of hepatocyte- or circulating-d...

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Bibliographic Details
Main Authors: Irma Garcia-Martinez, Rosa Alen, Laura Pereira, Adrián Povo-Retana, Alma M. Astudillo, Ana B. Hitos, Isabel Gomez-Hurtado, Eduardo Lopez-Collazo, Lisardo Boscá, Rubén Francés, Ignacio Lizasoain, María Ángeles Moro, Jesús Balsinde, Manuel Izquierdo, Ángela M. Valverde
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:JHEP Reports
Subjects:
NAFLD
Lipotoxicity
Inflammation
Insulin resistance
Extracellular vesicles
TLR4
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923000873

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http://www.sciencedirect.com/science/article/pii/S2589555923000873

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