Periodic synchronization of isolated network elements facilitates simulating and inferring gene regulatory networks including stochastic molecular kinetics

Periodic synchronization of isolated network elements facilitates simulating and inferring gene regulatory networks including stochastic molecular kinetics

Abstract Background The temporal progression of many fundamental processes in cells and organisms, including homeostasis, differentiation and development, are governed by gene regulatory networks (GRNs). GRNs balance fluctuations in the output of their genes, which trace back to the stochasticity of...

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Bibliographic Details
Main Authors: Johannes Hettich, J. Christof M. Gebhardt
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Bioinformatics
Subjects:
Gene regulatory network
Transcriptional bursting
Gene expression noise
Hybrid deterministic–stochastic simulation
Network inference
Online Access:https://doi.org/10.1186/s12859-021-04541-6

Internet

https://doi.org/10.1186/s12859-021-04541-6

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