Towards pharmacokinetic boosting of phenoxymethylpenicillin (penicillin-V) using probenecid for the treatment of bacterial infections

Towards pharmacokinetic boosting of phenoxymethylpenicillin (penicillin-V) using probenecid for the treatment of bacterial infections

Abstract In the face of increasing antimicrobial tolerance and resistance there is a global obligation to optimise oral antimicrobial dosing strategies including narrow spectrum penicillins, such as penicillin-V. We conducted a randomised, crossover study in healthy volunteers to characterise the in...

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Bibliographic Details
Main Authors: Richard C. Wilson, Alaa Riezk, Paul Arkell, Damien Ming, Ryan Armiger, Victoria Latham, Mark J. Gilchrist, Anne-Grete Märtson, William W. Hope, Alison H. Holmes, Timothy M. Rawson
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Scientific Reports
Subjects:
Probenecid
Beta lactam antibiotics
Pharmacokinetics
Pharmacodynamics
Dose optimisation
Online Access:https://doi.org/10.1038/s41598-024-67354-6

Internet

https://doi.org/10.1038/s41598-024-67354-6

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