Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62

Connexin (Cx) gap junction proteins are expressed by a multitude of cells and function as plasma membrane hemichannels or dock to form intercellular communication tunnels. Whilst Cx43 has garnered considerable attention, less is known about the structure and function of Cx62 channels. Platelets and...

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Bibliographic Details
Main Authors: Kirk A. Taylor, Amro Elgheznawy, Recep Adiyaman, Tyler L. Horn, Sarah Parkes, Craig E. Hughes, Liam J. McGuffin, Jonathan M. Gibbins
Format: Article
Language:English
Published: Ferrata Storti Foundation 2025-03-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/11966