Mechanisms of EGFR-TKI-Induced Apoptosis and Strategies Targeting Apoptosis in EGFR-Mutated Non-Small Cell Lung Cancer

Mechanisms of EGFR-TKI-Induced Apoptosis and Strategies Targeting Apoptosis in EGFR-Mutated Non-Small Cell Lung Cancer

Homeostasis is achieved by balancing cell survival and death. In cancer cells, especially those carrying driver mutations, the processes and signals that promote apoptosis are inhibited, facilitating the survival and proliferation of these dysregulated cells. Apoptosis induction is an important mech...

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Bibliographic Details
Main Authors: Shigetoshi Nishihara, Toshimitsu Yamaoka, Fumihiro Ishikawa, Kensuke Higuchi, Yuki Hasebe, Ryo Manabe, Yasunari Kishino, Sojiro Kusumoto, Koichi Ando, Yusuke Kuroda, Tohru Ohmori, Hironori Sagara, Hitoshi Yoshida, Junji Tsurutani
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Genes
Subjects:
EGFR-TKI
apoptosis
EGFR-mutated NSCLC
combination therapies
Online Access:https://www.mdpi.com/2073-4425/13/12/2183

Internet

https://www.mdpi.com/2073-4425/13/12/2183

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