Development of an LCâMS/MS method for determination of 2-oxo-clopidogrel in human plasma

A sensitive and selective liquid chromatographyâtandem mass spectrometric (LCâMS/MS) method was established to determine 2-oxo-clopidogrel, a crucial intermediate metabolite in human plasma. A chromatographic separation was performed on a Sapphire C18 column following a liquidâliquid extraction samp...

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Bibliographic Details
Main Authors: Yu-Han Li, Min Song, Tai-Jun Hang
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Journal of Pharmaceutical Analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177914000641