Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy

Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy

α-Synuclein (αS) is an intrinsically disordered and highly dynamic protein involved in dopamine release at presynaptic terminals. The abnormal aggregation of αS as mature fibrils into intraneuronal inclusion bodies is directly linked to Parkinson’s disease. Increasing experimental evidence suggests...

Full description

Bibliographic Details
Main Authors: Alessandra Bigi, Emilio Ermini, Serene W. Chen, Roberta Cascella, Cristina Cecchi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Life
Subjects:
synucleinopathies
protein aggregation
amyloid
toxic oligomers
Lewy bodies
PD
Online Access:https://www.mdpi.com/2075-1729/11/5/431

Internet

https://www.mdpi.com/2075-1729/11/5/431

Similar Items