Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-α therapy effectiveness

Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-α therapy effectiveness

Abstract Background Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory form of arthritis in which tumor necrosis factor (TNF)-α, a potent inducer of inflammatory response and a key regulator of innate immunity and of Th1 immune responses, plays a central role. NETosis is a mech...

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Bibliographic Details
Main Authors: Patricia Ruiz-Limon, Maria Lourdes Ladehesa-Pineda, Maria del Carmen Castro-Villegas, Maria del Carmen Abalos-Aguilera, Clementina Lopez-Medina, Chary Lopez-Pedrera, Nuria Barbarroja, Daniel Espejo-Peralbo, Jose Antonio Gonzalez-Reyes, Jose Manuel Villalba, Carlos Perez-Sanchez, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Pilar Font-Ugalde, Yolanda Jimenez-Gomez
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Biomedical Science
Subjects:
Biomarkers/NETosis/neutrophils/immunotherapy/pathogenesis/radiographic axial spondyloarthritis
Online Access:http://link.springer.com/article/10.1186/s12929-020-00634-1

Internet

http://link.springer.com/article/10.1186/s12929-020-00634-1

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