Drug-independent NADPH-consuming micelles collaborate with ROS-generator for cascade ferroptosis amplification by impairing redox homeostasis

Drug-independent NADPH-consuming micelles collaborate with ROS-generator for cascade ferroptosis amplification by impairing redox homeostasis

Ferroptosis as promising antitumor therapy strategy could be comprised by intracellular antioxidants, especially GSH and thioredoxin (Trx). They are both cofactors of Gpx4, the enzyme catalyzing the production of lipid peroxides to relieve oxidative stress, which drives the acquired ferroptosis resi...

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Bibliographic Details
Main Authors: Fangying Yu, Xuwei Shang, Zixu Wang, Yun Zhu, Simin Chen, Hong Yuan, Fuqiang Hu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Materials Today Bio
Subjects:
NADPH consumption
ROS generator
Cascade ferroptosis amplification
Redox homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006422003301

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http://www.sciencedirect.com/science/article/pii/S2590006422003301

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