Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner

Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner

GPR37L1 is a family A orphan G protein-coupled receptor (GPCR) with a putative role in blood pressure regulation and cardioprotection. In mice, genetic ablation of Gpr37l1 causes sex-dependent effects; female mice lacking Gpr37l1 (GPR37L1−/−) have a modest but significant elevation in blood pressure...

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Bibliographic Details
Main Authors: Margaret A. Mouat, Kristy L. Jackson, James L. J. Coleman, Madeleine R. Paterson, Robert M. Graham, Geoffrey A. Head, Nicola J. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
G protein-coupled receptor
sex differences
hypertension
blood pressure
radiotelemetry
heart rate variability
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.600266/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.600266/full

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