Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner

Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner

GPR37L1 is a family A orphan G protein-coupled receptor (GPCR) with a putative role in blood pressure regulation and cardioprotection. In mice, genetic ablation of Gpr37l1 causes sex-dependent effects; female mice lacking Gpr37l1 (GPR37L1−/−) have a modest but significant elevation in blood pressure...

Full description

Bibliographic Details
Main Authors:	Margaret A. Mouat, Kristy L. Jackson, James L. J. Coleman, Madeleine R. Paterson, Robert M. Graham, Geoffrey A. Head, Nicola J. Smith
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Pharmacology
Subjects:	G protein-coupled receptor sex differences hypertension blood pressure radiotelemetry heart rate variability
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2020.600266/full

Similar Items

Metabolic Profiling of Mice with Deletion of the Orphan G Protein-Coupled Receptor, GPR37L1
by: Margaret A. Mouat, et al.
Published: (2022-06-01)

Drug discovery opportunities at the endothelin B receptor-related orphan G protein-coupled receptors, GPR37 and GPR37L1
by: Nicola J Smith, et al.
Published: (2015-11-01)

The Use and Misuse of Wargames
by: Tom Mouat
Published: (2022-09-01)

Acute Cannabigerol Administration Lowers Blood Pressure in Mice
by: Victoria L. Vernail, et al.
Published: (2022-05-01)

Postdictadura y crítica cultural transatlántica
by: Ricardo Gutiérrez Mouat
Published: (2014-06-01)

Spatial organisation of badgers (<em>Meles meles</em>) in a medium-density population in Luxembourg
by: Alain C Frantz, et al.
Published: (2010-08-01)

WildTrack: An IoT System for Tracking Passive-RFID Microchipped Wildlife for Ecology Research
by: Robert Ross, et al.
Published: (2022-08-01)

Automated VHF Radiotelemetry Revealed Site-Specific Differences in Fall Migration Strategies of Semipalmated Sandpipers on Stopover in the Gulf of Maine
by: Rebecca L. Holberton, et al.
Published: (2019-09-01)

Rapid knockout and reporter mouse line generation and breeding colony establishment using EUCOMM conditional-ready embryonic stem cells: A case study
by: James L. J. Coleman, et al.
Published: (2015-06-01)

Age-associated B cells in viral infection.
by: Isobel C Mouat, et al.
Published: (2022-03-01)

Age-associated B cells in viral infection
by: Isobel C. Mouat, et al.
Published: (2022-03-01)

Emerging Roles for the Orphan GPCRs, GPR37 and GPR37 L1, in Stroke Pathophysiology
by: Sabra Mouhi, et al.
Published: (2022-04-01)

Home range and habitat use by pacas in a montane tropical forest in Bolivia
by: Camila BENAVIDES, et al.
Published: (2017-07-01)

Type 2 diabetes influences intraepithelial corneal nerve parameters and corneal stromal‐epithelial nerve penetration sites
by: Joshua Machet, et al.
Published: (2023-04-01)

Evaluation of Aeris mid-infrared absorption (MIRA), Picarro CRDS (cavity ring-down spectroscopy) G2307, and dinitrophenylhydrazine (DNPH)-based sampling for long-term formaldehyde monitoring efforts
by: A. P. Mouat, et al.
Published: (2024-04-01)

Habitat Requirements of Breeding Black-Backed Woodpeckers (Picoides arcticus) in Managed, Unburned Boreal Forest
by: Junior A. Tremblay, et al.
Published: (2009-06-01)

The effects of quercetin on SW480 human colon carcinoma cells: a proteomic study
by: Hargrove James L, et al.
Published: (2005-03-01)

Methods of amphibian tracking
by: V. Strus, et al.
Published: (2020-12-01)

Use of visual surveys and radiotelemetry reveals sources of detection bias for a cryptic snake at low densities
by: Scott M. Boback, et al.
Published: (2020-01-01)

Using incidental mark‐encounter data to improve survival estimation
by: Seth M. Harju, et al.
Published: (2020-01-01)

Integrating telemetry data into spatial capture–recapture modifies inferences on multi‐scale resource selection
by: Daniel W. Linden, et al.
Published: (2018-04-01)

Age-associated B cells are long-lasting effectors that impede latent γHV68 reactivation
by: Isobel C. Mouat, et al.
Published: (2022-12-01)

Home Range of the Caspian Whipsnake <i>Dolichophis caspius</i> (Gmelin, 1789) in a Threatened Peri-Urban Population
by: Thabang Rainett Teffo, et al.
Published: (2023-01-01)

An evaluation of translocation as a tool to reduce burrowing owl collisions at airports
by: Eduardo G. Santos, et al.
Published: (2023-03-01)

Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells
by: Isobel C Mouat, et al.
Published: (2021-06-01)

Design of Deployment Strategies to Monitor the Movement of Animals with Passive Electronic Devices
by: Laila D. Kazimierski, et al.
Published: (2021-01-01)

Variation in behavior drives multi‐scale responses to habitat conditions in timber rattlesnakes (Crotalus horridus)
by: Andrew S. Hoffman, et al.
Published: (2021-11-01)

Translocation and radiotelemetry monitoring of black-tailed marmosets, Callithrix (Mico) melanura(É. Geoffroy in Humboldt), in a wildlife rescue operation in Brazil
by: AAB. Marques, et al.

Habitat use by caribou in northern Alberta, Canada
by: Richard R. Schneider, et al.
Published: (2000-03-01)

Body Temperature and Activity Adaptation of Short Photoperiod-Exposed Djungarian Hamsters (Phodopus sungorus): Timing, Traits, and Torpor
by: Elena Haugg, et al.
Published: (2021-07-01)

Localizing Japanese toads in a mountainous terrain using drone-based radiotelemetry
by: Chiaki Yamato, et al.
Published: (2023-01-01)

Classifying the activity states of small vertebrates using automated VHF telemetry
by: Jannis Gottwald, et al.
Published: (2023-01-01)

Space Use by Brown Bears (Ursus arctos) in the Sikhote-Alin
by: Ivan V. Seryodkin, et al.
Published: (2019-12-01)

Mice Lacking Free Fatty Acid Receptor 1 (GPR40/FFAR1) are Protected Against Conjugated Linoleic Acid-Induced Fatty Liver but Develop Inflammation and Insulin Resistance in the Brain
by: Tina Sartorius, et al.
Published: (2015-04-01)

Recent Trends in Survival and Mortality of Wolves in Minnesota, United States
by: Stotra Chakrabarti, et al.
Published: (2022-06-01)

The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination
by: Curtis M. Hay, et al.
Published: (2021-11-01)

Increasing maternal age is associated with taller stature and reduced abdominal fat in their children.
by: Tim Savage, et al.
Published: (2013-01-01)

Ambito de hogar y utilización de hábitat de dos grupos de venados Cola Blanca Odocoileus virginianus (Artiodactyla: Cervidae) reubicados en un ambiente tropical
by: Joel C. Sáenz, et al.
Published: (1998-12-01)

Measurement report: Observations of long-lived volatile organic compounds from the 2019–2020 Australian wildfires during the COALA campaign
by: A. P. Mouat, et al.
Published: (2022-08-01)

The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse.
by: Waller-Evans, H, et al.
Published: (2010)