Intracellular survival of Streptococcus pneumoniae in human alveolar macrophages is augmented with HIV infection

Intracellular survival of Streptococcus pneumoniae in human alveolar macrophages is augmented with HIV infection

People Living with HIV (PLHIV) are at an increased risk of pneumococcal pneumonia than HIV-uninfected adults, but the reasons for this are still not well understood. We investigated whether alveolar macrophages (AM) mediated control of pneumococcal infection is impaired in PLHIV compared to HIV-unin...

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Bibliographic Details
Main Authors: Tinashe K. Nyazika, Lusako Sibale, Joseph Phiri, Megan De Ste Croix, Zydrune Jasiunaite, Christopher Mkandawire, Rose Malamba, Anstead Kankwatira, Miriam Manduwa, Daniela M. Ferreira, Tonney S. Nyirenda, Marco R. Oggioni, Henry C. Mwandumba, Kondwani C. Jambo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Streptococcus pneumoniae
alveolar macrophages
HIV
intracellular killing
lung
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.992659/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.992659/full

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