Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma

Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma

Abstract Integrins are a large family of adhesion molecules that mediate cell-cell and cell-extracellular matrix interactions. Among the 24 integrin isoforms, many have been found to be associated with tumor angiogenesis, tumor cell migration and proliferation, and metastasis. Integrins, especially...

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Bibliographic Details
Main Authors: Ruixia Huang, Einar K. Rofstad
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Integrin
Organ-specific metastasis
Malignant melanoma
Angiogenesis
Metastasis
Integrin inhibitors
Online Access:http://link.springer.com/article/10.1186/s13046-018-0763-x

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http://link.springer.com/article/10.1186/s13046-018-0763-x

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