Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.

Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.

To preserve genome integrity, the S-phase checkpoint senses damaged DNA or nucleotide depletion and when necessary, arrests replication progression and delays cell division. Previous studies, based on two pol2 mutants have suggested the involvement of DNA polymerase epsilon (Pol ε) in sensing DNA re...

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Bibliographic Details
Main Authors: Michał Dmowski, Justyna Rudzka, Judith L Campbell, Piotr Jonczyk, Iwona J Fijałkowska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5291541?pdf=render

Internet

http://europepmc.org/articles/PMC5291541?pdf=render

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