Concentration- and Time-Dependent Effects of Benzalkonium Chloride in Human Lung Epithelial Cells: Necrosis, Apoptosis, or Epithelial Mesenchymal Transition

Concentration- and Time-Dependent Effects of Benzalkonium Chloride in Human Lung Epithelial Cells: Necrosis, Apoptosis, or Epithelial Mesenchymal Transition

Benzalkonium chloride (BAC), an antimicrobial agent in inhalable medications and household sprays, has been reported to be toxic to pulmonary organs. Although cell membrane damage has been considered as the main cytotoxic mechanism of BAC, its concentration- and time-dependent cellular effects on lu...

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Bibliographic Details
Main Authors: Sou Hyun Kim, Doyoung Kwon, Seunghyun Lee, Seung Won Son, Jung-Taek Kwon, Pil-Je Kim, Yun-Hee Lee, Young-Suk Jung
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Toxics
Subjects:
benzalkonium chloride
lung epithelial cells
cytotoxicity
endoplasmic reticulum stress
epithelial–mesenchymal transition
Online Access:https://www.mdpi.com/2305-6304/8/1/17

Internet

https://www.mdpi.com/2305-6304/8/1/17

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