Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis

Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis

Abstract Leishmaniasis is a neglected protozoan disease affecting over 12 million people globally with no approved vaccines for human use. New World cutaneous leishmaniasis (CL) caused by L. mexicana is characterized by the development of chronic non-healing skin lesions. Using the CRISPR/Cas9 techn...

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Bibliographic Details
Main Authors: Greta Volpedo, Thalia Pacheco-Fernandez, Erin A. Holcomb, Wen-Wei Zhang, Patrick Lypaczewski, Blake Cox, Rebecca Fultz, Chelsea Mishan, Chaitenya Verma, Ryan H. Huston, Abigail R. Wharton, Ranadhir Dey, Subir Karmakar, Steve Oghumu, Shinjiro Hamano, Sreenivas Gannavaram, Hira L. Nakhasi, Greg Matlashewski, Abhay R. Satoskar
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00449-1

Internet

https://doi.org/10.1038/s41541-022-00449-1

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