Eltrombopag directly activates BAK and induces apoptosis

Eltrombopag directly activates BAK and induces apoptosis

Abstract Small molecule direct BAK activators can potentially be used for the development of anti-cancer drugs or as tools to study BAK activation. The thrombopoietin receptor agonist eltrombopag (Eltro) inhibits BAX activation and BAX-mediated apoptosis. Here we report that, in contrast to its func...

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Bibliographic Details
Main Authors: Meng Chen, Lei Hu, Xuyuan Bao, Kaiqin Ye, Yunjian Li, Zhiyong Zhang, Scott H. Kaufmann, Jun Xiao, Haiming Dai
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05918-6

Internet

https://doi.org/10.1038/s41419-023-05918-6

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