Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication

Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication

Viral replication often depends on RNA maturation and degradation processes catalyzed by viral ribonucleases, which are therefore candidate targets for antiviral drugs. Here, we synthesized and studied the antiviral properties of a novel nitrocatechol compound (<b>1c</b>) and other analo...

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Bibliographic Details
Main Authors: Abhishek Asthana, Angela Corona, Woo-Jin Shin, Mi-Jeong Kwak, Christina Gaughan, Enzo Tramontano, Jae U. Jung, Rainer Schobert, Babal Kant Jha, Robert H. Silverman, Bernhard Biersack
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Viruses
Subjects:
ribonucleases
enzyme inhibitors
HIV-1 RNase H
SARS-CoV-2 nsp14
coronavirus
HIV
Online Access:https://www.mdpi.com/1999-4915/15/7/1539

Internet

https://www.mdpi.com/1999-4915/15/7/1539

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