PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death

PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death

Successful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs) and the underlying mechanisms. Treatment with PBI...

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Bibliographic Details
Main Authors: Sharmistha Chakraborty, Daoyan Wei, Megan Tran, Frederick F Lang, Robert A Newman, Peiying Yang
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
PBI-05204
Glioblastoma stem cells
CD44
GRP78
Necroptosis
Oleandrin
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558624000502

Internet

http://www.sciencedirect.com/science/article/pii/S1476558624000502

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