Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer
The SomaGene tool is developed to identify non-coding RNAs (ncRNAs) mutated in breast cancer but can be used for other cancers. Candidate ncRNAs are shown to be enriched for regulatory features and to contain specific trait loci polymorphisms.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03528-0 |
| _version_ | 1828803904711688192 |
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| author | Narges Rezaie Masroor Bayati Mehrab Hamidi Maedeh Sadat Tahaei Sadegh Khorasani Nigel H. Lovell James Breen Hamid R. Rabiee Hamid Alinejad-Rokny |
| author_facet | Narges Rezaie Masroor Bayati Mehrab Hamidi Maedeh Sadat Tahaei Sadegh Khorasani Nigel H. Lovell James Breen Hamid R. Rabiee Hamid Alinejad-Rokny |
| author_sort | Narges Rezaie |
| collection | DOAJ |
| description | The SomaGene tool is developed to identify non-coding RNAs (ncRNAs) mutated in breast cancer but can be used for other cancers. Candidate ncRNAs are shown to be enriched for regulatory features and to contain specific trait loci polymorphisms. |
| first_indexed | 2024-12-12T07:31:06Z |
| format | Article |
| id | doaj.art-97982823a65f415f8a5d8eed4ea50e41 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-12T07:31:06Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-97982823a65f415f8a5d8eed4ea50e412022-12-22T00:33:01ZengNature PortfolioCommunications Biology2399-36422022-06-015111310.1038/s42003-022-03528-0Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancerNarges Rezaie0Masroor Bayati1Mehrab Hamidi2Maedeh Sadat Tahaei3Sadegh Khorasani4Nigel H. Lovell5James Breen6Hamid R. Rabiee7Hamid Alinejad-Rokny8Center for Complex Biological Systems, University of California IrvineBioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of TechnologyBioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of TechnologyBioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of TechnologyBioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of TechnologyTyree Institute of Health Engineering and The Graduate School of Biomedical Engineering, UNSW SydneySouth Australian Health & Medical Research InstituteBioinformatics and Computational Biology Lab, Department of Computer Engineering, Sharif University of TechnologyBioMedical Machine Learning Lab (BML), The Graduate School of Biomedical Engineering, UNSW SydneyThe SomaGene tool is developed to identify non-coding RNAs (ncRNAs) mutated in breast cancer but can be used for other cancers. Candidate ncRNAs are shown to be enriched for regulatory features and to contain specific trait loci polymorphisms.https://doi.org/10.1038/s42003-022-03528-0 |
| spellingShingle | Narges Rezaie Masroor Bayati Mehrab Hamidi Maedeh Sadat Tahaei Sadegh Khorasani Nigel H. Lovell James Breen Hamid R. Rabiee Hamid Alinejad-Rokny Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer Communications Biology |
| title | Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer |
| title_full | Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer |
| title_fullStr | Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer |
| title_full_unstemmed | Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer |
| title_short | Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer |
| title_sort | somatic point mutations are enriched in non coding rnas with possible regulatory function in breast cancer |
| url | https://doi.org/10.1038/s42003-022-03528-0 |
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