Improvement of Biophysical Properties and Affinity of a Human Anti-L1CAM Therapeutic Antibody through Antibody Engineering Based on Computational Methods

Improvement of Biophysical Properties and Affinity of a Human Anti-L1CAM Therapeutic Antibody through Antibody Engineering Based on Computational Methods

The biophysical properties of therapeutic antibodies influence their manufacturability, efficacy, and safety. To develop an anti-cancer antibody, we previously generated a human monoclonal antibody (Ab417) that specifically binds to L1 cell adhesion molecule with a high affinity, and we validated it...

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Bibliographic Details
Main Authors: Heesu Chae, Seulki Cho, Munsik Jeong, Kiyoung Kwon, Dongwook Choi, Jaeyoung Lee, Woosuk Nam, Jisu Hong, Jiwoo Lee, Seonjoo Yoon, Hyojeong Hong
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
therapeutic antibody
anti-cancer antibody
antibody engineering
biophysical properties
computational methods
research cell bank
Online Access:https://www.mdpi.com/1422-0067/22/13/6696

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https://www.mdpi.com/1422-0067/22/13/6696

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