Improvement of Biophysical Properties and Affinity of a Human Anti-L1CAM Therapeutic Antibody through Antibody Engineering Based on Computational Methods
The biophysical properties of therapeutic antibodies influence their manufacturability, efficacy, and safety. To develop an anti-cancer antibody, we previously generated a human monoclonal antibody (Ab417) that specifically binds to L1 cell adhesion molecule with a high affinity, and we validated it...
Main Authors: | Heesu Chae, Seulki Cho, Munsik Jeong, Kiyoung Kwon, Dongwook Choi, Jaeyoung Lee, Woosuk Nam, Jisu Hong, Jiwoo Lee, Seonjoo Yoon, Hyojeong Hong |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-06-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/13/6696 |
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