Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

Abstract Background The aim of this study was to compare the binding properties of several tau positron emission tomography tracers—THK5117, THK5351, T807 (also known as AV1451; flortaucipir), and PBB3—head to head in the same human brain tissue. Methods Binding assays were performed to compare the...

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Bibliographic Details
Main Authors: Laetitia Lemoine, Per-Göran Gillberg, Marie Svedberg, Vladimir Stepanov, Zhisheng Jia, Jinghai Huang, Sangram Nag, He Tian, Bernardino Ghetti, Nobuyuki Okamura, Makoto Higuchi, Christer Halldin, Agneta Nordberg
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
THK5117
11C-THK5351
T807
AV1451
PBB3
Online Access:http://link.springer.com/article/10.1186/s13195-017-0325-z

Internet

http://link.springer.com/article/10.1186/s13195-017-0325-z

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