Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain

Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain

Keratin intermediate filaments constitute the primary cytoskeletal component of epithelial cells. Numerous human disease phenotypes related to keratin mutation remain mechanistically elusive. Our recent crystal structures of the helix 1B heterotetramer from keratin 1/10 enabled further investigation...

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Bibliographic Details
Main Authors: Alexander J. Hinbest, Sherif A. Eldirany, Minh Ho, Christopher G. Bunick
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
keratin
intermediate filament
structure
modeling
skin disease
liver disease
Online Access:https://www.mdpi.com/1422-0067/21/18/6641

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https://www.mdpi.com/1422-0067/21/18/6641

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