Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs

Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs

Basal-like triple-negative breast cancer (TNBC) tumor cells are difficult to eliminate due to resistance mechanisms that promote survival. While this breast cancer subtype has low PIK3CA mutation rates when compared to estrogen receptor-positive (ER+) breast cancers, most basal-like TNBCs have an ov...

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Bibliographic Details
Main Authors: David C. Boyd, Emily K. Zboril, Amy L. Olex, Tess J. Leftwich, Nicole S. Hairr, Holly A. Byers, Aaron D. Valentine, Julia E. Altman, Mohammad A. Alzubi, Jacqueline M. Grible, Scott A. Turner, Andrea Ferreira-Gonzalez, Mikhail G. Dozmorov, J. Chuck Harrell
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
patient-derived xenograft
precision medicine
basal-like breast cancer
triple-negative breast cancer
synergism
BYL-719 (alpelisib)
Online Access:https://www.mdpi.com/2072-6694/15/5/1582

Internet

https://www.mdpi.com/2072-6694/15/5/1582

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