MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells

MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells

Modulations in cell surface receptor ectodomain proteolytic shedding impact on receptor function and cancer biomarker expression. As such, heavily pursued therapeutic avenues have exploited LDL receptor-related protein-1 (LRP-1)-mediated capacity in internalizing Angiopep-2 (An2), a brain-penetratin...

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Bibliographic Details
Main Authors: Jonathan Pratt, Khadidja Haidara, Borhane Annabi
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
blood–brain tumor barrier
MT1-MMP
LRP-1
glioblastoma
Angiopep-2
Online Access:https://www.mdpi.com/1422-0067/23/22/14214

Internet

https://www.mdpi.com/1422-0067/23/22/14214

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