Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion
Amoxicillin-loaded microcapsules were prepared by ionotropic gelation of sodium alginate (ALG) with chitosan (CS) in presence of calcium chloride as gastroretentive delivery system. The effect of pH, concentration of ALG, CS and calcium chloride, and drug : ALG ratio were optimized in this study for...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Journal of Advanced Pharmaceutical Technology & Research |
| Subjects: | |
| Online Access: | http://www.japtr.org/article.asp?issn=2231-4040;year=2012;volume=3;issue=1;spage=68;epage=74;aulast=Arora |
| _version_ | 1818856964478730240 |
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| author | Saahil Arora R D Budhiraja |
| author_facet | Saahil Arora R D Budhiraja |
| author_sort | Saahil Arora |
| collection | DOAJ |
| description | Amoxicillin-loaded microcapsules were prepared by ionotropic gelation of sodium alginate (ALG) with chitosan (CS) in presence of calcium chloride as gastroretentive delivery system. The effect of pH, concentration of ALG, CS and calcium chloride, and drug : ALG ratio were optimized in this study for minimizing the degradation of drug in acidic environment and increasing the loading efficacy and mucoadhesive efficiency of microcapsules. The optimum condition for prepared CS-ALG microcapsules was 2%w/v ALG, 0.75%w/v CS (pH5.0), and 1.0% w/v calcium chloride. The resulting microcapsules had drug entrapment efficiency of 84% and average size of 840 mm. CS concentration significantly influenced particle size and encapsulation efficiency of CS-ALG microcapsules (P<0.05). Decrease in the drug: ALG ratio resulted in an increased release of amoxicillin in acidic media. The relative decomposition of drug after encapsulation in CS-ALG microcapsules was decreased to 20.7%, 41.9%, and 83.3% in 2, 4, and 8 hours, respectively. |
| first_indexed | 2024-12-19T08:32:52Z |
| format | Article |
| id | doaj.art-97a5b70f78f64e3ab2c62dac3a832dd3 |
| institution | Directory Open Access Journal |
| issn | 2231-4040 0976-2094 |
| language | English |
| last_indexed | 2024-12-19T08:32:52Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj.art-97a5b70f78f64e3ab2c62dac3a832dd32022-12-21T20:29:08ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942012-01-0131687410.4103/2231-4040.93555Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesionSaahil AroraR D BudhirajaAmoxicillin-loaded microcapsules were prepared by ionotropic gelation of sodium alginate (ALG) with chitosan (CS) in presence of calcium chloride as gastroretentive delivery system. The effect of pH, concentration of ALG, CS and calcium chloride, and drug : ALG ratio were optimized in this study for minimizing the degradation of drug in acidic environment and increasing the loading efficacy and mucoadhesive efficiency of microcapsules. The optimum condition for prepared CS-ALG microcapsules was 2%w/v ALG, 0.75%w/v CS (pH5.0), and 1.0% w/v calcium chloride. The resulting microcapsules had drug entrapment efficiency of 84% and average size of 840 mm. CS concentration significantly influenced particle size and encapsulation efficiency of CS-ALG microcapsules (P<0.05). Decrease in the drug: ALG ratio resulted in an increased release of amoxicillin in acidic media. The relative decomposition of drug after encapsulation in CS-ALG microcapsules was decreased to 20.7%, 41.9%, and 83.3% in 2, 4, and 8 hours, respectively.http://www.japtr.org/article.asp?issn=2231-4040;year=2012;volume=3;issue=1;spage=68;epage=74;aulast=AroraGastroretentive delivery systemHelicobacter pyloripeptic ulcersodium alginate |
| spellingShingle | Saahil Arora R D Budhiraja Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion Journal of Advanced Pharmaceutical Technology & Research Gastroretentive delivery system Helicobacter pylori peptic ulcer sodium alginate |
| title | Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion |
| title_full | Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion |
| title_fullStr | Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion |
| title_full_unstemmed | Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion |
| title_short | Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion |
| title_sort | chitosan alginate microcapsules of amoxicillin for gastric stability and mucoadhesion |
| topic | Gastroretentive delivery system Helicobacter pylori peptic ulcer sodium alginate |
| url | http://www.japtr.org/article.asp?issn=2231-4040;year=2012;volume=3;issue=1;spage=68;epage=74;aulast=Arora |
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