Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome.

Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome.

Increased transforming growth factor-β (TGF-β) signaling contributes to the pathophysiology of aortic aneurysm in Marfan syndrome (MFS). Recent reports indicate that a small but significant number of inflammatory cells are infiltrated into the aortic media and adventitia in MFS. However, little is k...

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Main Authors: Hironori Hara, Sonoko Maemura, Takayuki Fujiwara, Norifumi Takeda, Satoshi Ishii, Hiroki Yagi, Takaaki Suzuki, Mutsuo Harada, Haruhiro Toko, Tsubasa Kanaya, Hideaki Ijichi, Harold L Moses, Eiki Takimoto, Hiroyuki Morita, Hiroshi Akazawa, Issei Komuro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0239908

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https://doi.org/10.1371/journal.pone.0239908

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