Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV)
Highlights Anti-cancer effects of hAEC depend on cancer type. Cross-reactive humoral responses do not mediate anti-cancer effects of hAEC. Anti-cancer effects of hAECs are mainly mediated by small-extracellular vesicles (sEV). hAEC-derived sEV (AD-sEV) trigger the Warburg’s effect leading to Arginin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02755-z |
| _version_ | 1829096518110412800 |
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| author | Mohammad-Reza Bolouri Roya Ghods Kayhan Zarnani Sedigheh Vafaei Reza Falak Amir-Hassan Zarnani |
| author_facet | Mohammad-Reza Bolouri Roya Ghods Kayhan Zarnani Sedigheh Vafaei Reza Falak Amir-Hassan Zarnani |
| author_sort | Mohammad-Reza Bolouri |
| collection | DOAJ |
| description | Highlights Anti-cancer effects of hAEC depend on cancer type. Cross-reactive humoral responses do not mediate anti-cancer effects of hAEC. Anti-cancer effects of hAECs are mainly mediated by small-extracellular vesicles (sEV). hAEC-derived sEV (AD-sEV) trigger the Warburg’s effect leading to Arginine consumption and cancer cell apoptosis. AD-sEV substantially inhibits tumor development and increases survival and CTL responses. |
| first_indexed | 2024-04-11T08:58:33Z |
| format | Article |
| id | doaj.art-97a6717821df433da8b431c3c3a1bc5a |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-11T08:58:33Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-97a6717821df433da8b431c3c3a1bc5a2022-12-22T04:33:08ZengBMCCancer Cell International1475-28672022-10-0122111810.1186/s12935-022-02755-zHuman amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV)Mohammad-Reza Bolouri0Roya Ghods1Kayhan Zarnani2Sedigheh Vafaei3Reza Falak4Amir-Hassan Zarnani5Department of Immunology, Iran University of Medical SciencesOncopathology Research Center, Iran University of Medical SciencesDepartment of Immunology, School of Public Health, Tehran University of Medical SciencesBiotechnology Research Center, Avicenna Research Institute, ACECRDepartment of Immunology, Iran University of Medical SciencesDepartment of Immunology, School of Public Health, Tehran University of Medical SciencesHighlights Anti-cancer effects of hAEC depend on cancer type. Cross-reactive humoral responses do not mediate anti-cancer effects of hAEC. Anti-cancer effects of hAECs are mainly mediated by small-extracellular vesicles (sEV). hAEC-derived sEV (AD-sEV) trigger the Warburg’s effect leading to Arginine consumption and cancer cell apoptosis. AD-sEV substantially inhibits tumor development and increases survival and CTL responses.https://doi.org/10.1186/s12935-022-02755-zStem cellsHuman amniotic epithelial cellCancerSmall extracellular vesicles (sEV)Cytotoxic T lymphocyteWarburg’s effect |
| spellingShingle | Mohammad-Reza Bolouri Roya Ghods Kayhan Zarnani Sedigheh Vafaei Reza Falak Amir-Hassan Zarnani Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV) Cancer Cell International Stem cells Human amniotic epithelial cell Cancer Small extracellular vesicles (sEV) Cytotoxic T lymphocyte Warburg’s effect |
| title | Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV) |
| title_full | Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV) |
| title_fullStr | Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV) |
| title_full_unstemmed | Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV) |
| title_short | Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV) |
| title_sort | human amniotic epithelial cells exert anti cancer effects through secretion of immunomodulatory small extracellular vesicles sev |
| topic | Stem cells Human amniotic epithelial cell Cancer Small extracellular vesicles (sEV) Cytotoxic T lymphocyte Warburg’s effect |
| url | https://doi.org/10.1186/s12935-022-02755-z |
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