Comparative analysis of SARS-CoV-2 variants Alpha (B.1.1.7), Gamma (P.1), Zeta (P.2) and Delta (B.1.617.2) in Vero-E6 cells: ultrastructural characterization of cytopathology and replication kinetics

Comparative analysis of SARS-CoV-2 variants Alpha (B.1.1.7), Gamma (P.1), Zeta (P.2) and Delta (B.1.617.2) in Vero-E6 cells: ultrastructural characterization of cytopathology and replication kinetics

This study compares the effects of virus-cell interactions among SARS-CoV-2 variants of concern (VOCs) isolated in Brazil in 2021, hypothesizing a correlation between cellular alterations and mortality and between viral load and transmissibility. For this purpose, reference isolates of Alpha, Gamma,...

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Bibliographic Details
Main Authors: Debora Ferreira Barreto Vieira, Derick Mendes Bandeira, Marcos Alexandre Nunes da Silva, Ana Luisa Teixeira de Almeida, Mia Araújo, Ana Beatriz Machado, Luis Fernando Lopez Tort, Valéria Pereira Nacife, Marilda M. Siqueira, Fernando Couto Motta, Alex Pauvolid-Corrêa, Ortrud Monika Barth
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Brazilian Journal of Infectious Diseases
Subjects:
SARS-CoV-2
Vero-E6 cells
Variant of concern
Ultrastructural studies
Cytopathology
Transmission electron microscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S1413867023009662

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